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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Spontaneous fibrosarcoma in an experimental aged Lewis rat |
| 掲載誌名 | 正式名：LABORATORY ANIMALS ISSNコード：00236772 |
| 出版社 | ROYAL SOC MEDICINE PRESS LTD |
| 巻・号・頁 | 46(4),pp.352-355 |
| 著者・共著者 | Ryo Sasaki,Hajime Matsumine,Naoyuki Matsumoto,Yorikatsu Watanabe,Masayuki Yamato,Teruo Okano,Tomohiro Ando |
| 発行年月 | 2012/10 |
| 概要 | This case report describes the results of the gross pathological, histological and immunohistological examinations of a fibrosarcoma that spontaneously developed in the left neck region of an aged male Lewis rat that participated in a long-term facial nerve regeneration study. A 10 mm long polylactic acid (PLA) tube was implanted into a 7 mm critical defect gap of the buccal branch of the left facial nerve of a male eight-week-old Lewis rat. Forty-two weeks after implantation, an approximately 8 cm x 9 cm x 2.5 cm rapidly growing mass with ulceration of the overlying skin was found in the left neck region. Gross examination of the tumour and the surrounding tissues before tumour excision revealed that the tumour had clear boundaries, and had not invaded any facial tissues, the facial nerve and the PLA nerve guide. Gross examination of the tumour's cut surface revealed that the tumour comprised numerous smooth nodules with a homogeneous white tan colour. Examination of the haematoxylin and eosin-stained sections of the tumour revealed that the tumour was predominantly composed of bundles of spindle-shaped atypical proliferating cells that were mixedwith bundles of collagen fibres a |
| DOI | 10.1258/la.2012.011174 |