ハヤカワ トオル   Hayakawa Toru
  早川 徹
   所属   鶴見大学・鶴見大学短期大学部 学長・副学長  学長・副学長 副学長
   職種   副学長
論文種別 【査読あり】 研究論文(学術雑誌)
言語種別 英語
査読の有無 査読あり
表題 Hydroxyapatite coating for titanium fibre mesh scaffold enhances osteoblast activity and bone tissue formation.
掲載誌名 正式名:International journal of oral and maxillofacial surgery
略  称:Int J Oral Maxillofac Surg
ISSNコード:13990020/09015027
掲載区分国外
巻・号・頁 41(10),pp.1304-1309
著者・共著者 Hirota Makoto, Hayakawa Tohru, Yoshinari Masao, Ametani Akihiro, Shima Takaki, Monden Yuka, Ozawa Tomomichi, Sato Mitsunobu, Koyama Chika, Tamai Naoto, Iwai Toshinori, Tohnai Iwai
発行年月 2012/10
概要 This study investigated the bone regeneration properties of titanium fibre mesh as a tissue engineering material. A thin hydroxyapatite (HA) coating on the titanium fibre web was created using the developed molecular precursor method without losing the complex interior structure. HA-coated titanium fibre mesh showed apatite crystal formation in vitro in a human osteoblast culture. Titanium fibre mesh discs with or without a thin HA coating were implanted into rat cranial bone defects, and the animals were killed at 2 and 4 weeks. The in vivo experience revealed that the amount of newly formed bone was significantly higher in the HA-coated titanium fibre mesh than in the non-coated titanium fibre mesh 2 weeks after implantation. These results suggest that thin HA coating enhances osteoblast activity and bone regeneration in the titanium fibre mesh scaffold. Thin HA-coating improved the ability of titanium fibre mesh to act as a bone regeneration scaffold.
DOI 10.1016/j.ijom.2011.12.035
PMID 22513355