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ハヤカワ トオル
Hayakawa Toru
早川 徹 所属 鶴見大学・鶴見大学短期大学部 学長・副学長 学長・副学長 副学長 職種 副学長 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Polycationic protamine for water-insoluble complex formation with DNA. |
| 掲載誌名 | 正式名：Dental materials journal 略 称：Dent Mater J ISSNコード：18811361/02874547 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 29(5),pp.529-35 |
| 著者・共著者 | Fukushima Tadao, Ohno Jun, Hayakawa Tohru, Imayoshi Rieko, Kawaguchi Minoru, Doi Yutaka, Kanaya Keiichi, Mitarai Makoto |
| 発行年月 | 2010/10 |
| 概要 | The DNA/protamine complex was prepared by a reaction between DNA and protamine sulfate solutions with stirring, and its cell viability, antibacterial effect and histopathological responses were examined. A water-insoluble white powder, DNA/protamine complex, with a porous structure was obtained. The molar binding ratio of the complex prepared from a solution containing equal amounts of DNA and protamine sulfate by weight was 0.038 and the efficiency of complex formation was 61%. In a cell culture test using MC-3T3-E1 mouse osteoblast cells, the complex showed less cytotoxicity than protamine sulfate alone and cell viabilities were more than 98%. |
| DOI | 10.4012/dmj.2009-131 |
| PMID | 20733264 |