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ハヤカワ トオル
Hayakawa Toru
早川 徹 所属 鶴見大学・鶴見大学短期大学部 学長・副学長 学長・副学長 副学長 職種 副学長 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Prevention of biofilm formation on titanium surfaces modified with conjugated molecules comprised of antimicrobial and titanium-binding peptides. |
| 掲載誌名 | 正式名：Biofouling 略 称：Biofouling ISSNコード：10292454/08927014 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 26(1),pp.103-10 |
| 著者・共著者 | Yoshinari Masao, Kato Tetsuo, Matsuzaka Kenichi, Hayakawa Tohru, Shiba Kiyotaka |
| 発行年月 | 2010/01 |
| 概要 | Specific binding of antimicrobial peptides to titanium (Ti) surfaces may serve to prevent biofilm formation, leading to a reduction in peri-implantitis. This study evaluated the binding behavior of conjugated molecules consisting of antimicrobial and hexapeptidic Ti-binding peptides (minTBP-1) using the quartz crystal microbalance (QCM-D) technique, and investigated the effect of modification of Ti surfaces with these peptides on the bioactivity of Porphyromonas gingivalis. Four kinds of peptide were prepared: histatin 5 (DSHAKRHHGYKRKFHEKHHSHRGY), minTBP-1 + histatin 5 (RKLPDAPDSHAKRHHGYKRKFHEKHHSHRGY), lactoferricin (FQWQRNMRKVR), and minTBP-1 + lactoferricin (RKLPDAPGGFQWQRNMRKVR). The QCM-D analysis demonstrated that significantly larger increases in peptide adsorption were observed in the conjugated peptides than in antimicrobial peptides alone. |
| DOI | 10.1080/08927010903216572 |
| PMID | 20390560 |