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サトムラ カズヒト
Satomura Kazuhito
里村 一人 所属 鶴見大学 歯学部 歯学科 口腔内科学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Possible involvement of stem cell factor and endothelin-1 in the emergence of pigmented squamous cell carcinoma in oral mucosa. |
| 掲載誌名 | 正式名：Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 略 称：J Oral Pathol Med ISSNコード：09042512/09042512 |
| 掲載区分 | 国外 |
| 巻・号・頁 | 36(10),pp.621-4 |
| 著者・共著者 | Satomura Kazuhito, Tokuyama Reiko, Yamasaki Yasuhumi, Yuasa Tetsuya, Tatehara Seiko, Ishimaru Naozumi, Hayashi Yoshio, Nagayama Masaru |
| 担当区分 | 筆頭著者 |
| 発行年月 | 2007/11 |
| 概要 | We present here the clinical, morphological and immunohistochemical features of a pigmented squamous cell carcinoma (SCC) in the oral mucosa of the hard palate of a 76-year-old Japanese man. He underwent a partial resection of the maxilla subsequent to radiotherapy. The tumor was typical, moderately well-differentiated SCC but had many melanocytes (melanocytosis) within it. Immunohistochemical analysis for stem cell factor (SCF) and endothelin-1, both of which are known to stimulate proliferation and differentiation of melanocytes, revealed prominent expression of both factors in the neoplastic squamous cells of the pigmented SCC, while the non-pigmented oral SCC showed little sign of either factor. These findings strongly suggest that SCF and endothelin-1 secreted by neoplasmic squamous cells are involved in the emergence of a rare variant of oral SCC. |
| DOI | 10.1111/j.1600-0714.2007.00587.x |
| PMID | 17944756 |