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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Sodium Butyrate, a Histone Deacetylase Inhibitor, Regulates Lymphangiogenic Factors in Oral Cancer Cell Line HSC-3 |
| 掲載誌名 | 正式名：ANTICANCER RESEARCH ISSNコード：02507005 |
| 出版社 | INT INST ANTICANCER RESEARCH |
| 巻・号・頁 | 34(4),pp.1701-1708 |
| 著者・共著者 | Takashi Yamamura,Naoyuki Matsumoto,Yasuyoshi Matsue,Michisato Okudera,Youichi Nishikawa,Yoshimitsu Abiko,Kazuo Komiyama |
| 発行年月 | 2014/04 |
| 概要 | Aim: Tumor angiogenesis is a focus of molecularly-targeted therapies. This study investigated the effect of sodium butyrate (SB), a histone deacetylase inhibitor, on the synthesis of antiangiogenic and lymphangiogenic factors in oral squamous cell carcinoma. Design: Gene alterations in HSC-3 cells were assessed using cDNA microarrays before and after treatment with SB. The mRNA and protein expression of lymphangiogenic factors were also assessed by quantitative PCR, western blotting and immunocytochemistry. Results: Microarray analysis revealed that treatment with SB led to altered expression of angio genesis-related gene expression. The quantitative polymerase chain reaction showed that platelet-derived growth factor-B, angiopoietin-2, vascular endothelial growth factor (VEGF)-C, and VEGFD were down-regulated. Western blotting and immunocytochemistry confirmed reduced protein synthesis of VEGFC. Conclusion: SB inhibits expression of lymphangiogenic factors in HSC-3 cells. Within the limitations of the present study, SB may have potential as an anti-metastatic pro-drug for oralcancer. |