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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Detection of fascin and CCR-7 positive mature dendritic cells in oral lichen planus |
| 掲載誌名 | 正式名：JOURNAL OF ORAL PATHOLOGY&MEDICINE ISSNコード：09042512 |
| 出版社 | WILEY-BLACKWELL PUBLISHING, INC |
| 巻・号・頁 | 38(4),pp.334-342 |
| 著者・共著者 | Shotaro Mukae,Yasuhiro Okazaki,Hirotaka Tsuda,Koichi Nagai,Naoyuki Matsumoto,Toyoko Ochiai,Hidero Oki,Kazuo Komiyama |
| 発行年月 | 2009/04 |
| 概要 | Dendritic cells (DC) play a crucial role in the pathogenesis of oral lichen planus (OLP) with respect to antigens presented to T cells. We performed immunohistochemical analysis to elucidate the process of activation of DC in OLP.Thirty biopsy specimens were obtained from the patients with OLP. The expressions of CD1a, Langerin, S-100, fascin, chemokine receptor-7 (CCR-7), D2-40, cyclooxygenase-2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) in DC from OLP and disease free control were investigated using specific antibodies. The distribution and number (1 mm(2)) of DC were assessed in the intra-epithelium and the submucosa specimens. Correlation between the number of DC and epithelium thickness was also determined.Immature DC (Langerin(+), CD1a(+), and S-100(+)) were identified in the epithelia from OLP patients and control, though the numbers of Langerin(+) and CD1a(+) positive cells were decreased in the OLP samples as compared to the control. Mature DC (fascin(+)) were identified in the submucosa specimens, not found in the epithelium from OLP or control. Double immunostaining revealed DC positive for fascin and CCR-7 in the submucosa, which had migrated into D2 |
| DOI | 10.1111/j.1600-0714.2008.00741.x |