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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Histochemical and Radiological Study of Bone Regeneration by the Combinatorial Use of Tetrapod-Shaped Artificial Bone and Collagen |
| 掲載誌名 | 正式名：JOURNAL OF HARD TISSUE BIOLOGY ISSNコード：13417649 |
| 出版社 | JOURNAL HARD TISSUE BIOLOGY |
| 巻・号・頁 | 24(2),pp.199-209 |
| 著者・共著者 | Takeshi Uryu,Naoyuki Matsumoto,Shunsuke Namaki,Takayuki Mashimo,Takaaki Tamagawa,Tomohiro Yasumitsu,Michisato Okudera,Kazuo Komiyama,Ung-il Chung,Kazuya Honda,Yoshinori Arai,Yoshiyuki Yonehara |
| 発行年月 | 2015/04 |
| 概要 | The purpose of this study was to examine the potential application of a tetrapod-shaped artificial bone, Tetrabone (TB), along with collagen, in bone regeneration. Nine-week-old male Wistar rats (n = 60) were used. An 8 mm-diameter defect was filled with TB, collagen, or a combination mixture ofTB and collagen, and left untreated in the control group. The results showed higher volumes of the newly formed bones in the combination group than in the TB group or control group at each time point by micro-CT analysis (P< 0.05). The TB group showed bone formation that extended from the existing bone. In contrast, the collagen group showed disseminated bone formation in the defect. Runx2- and TGF beta-positive cells were identified at collagen and TB surfaces. The bone formation of the combination group had characteristics of both TB and collagen groups. The combination group showed bone formation from the existing bone edge and in the entire part of the defect. Thus, the combinatorial use of TB and collagen would be an effective strategy for the treatment of bone defect. |
| DOI | 10.2485/jhtb.24.199 |