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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | CD105 expression in oral capillary hemangiomas and cavernous hemangiomas |
| 掲載誌名 | 正式名：JOURNAL OF ORAL SCIENCE ISSNコード：13434934 |
| 出版社 | NIHON UNIV, SCHOOL DENTISTRY |
| 巻・号・頁 | 57(1),pp.45-53 |
| 著者・共著者 | Naoyuki Matsumoto,Motomi Tsuchiya,Shouta Nomoto,Yasuyoshi Matsue,Yohichi Nishikawa,Tsuyoshi Takamura,Hidero Oki,Kazuo Komiyama |
| 発行年月 | 2015/03 |
| 概要 | Capillary hemangioma (capillary lobular hemangioma) and cavernous hemangioma (venous malformation) are relatively common oral tumors/malformations and are characterized by increased numbers of normal and abnormal blood vessels. However, the causes of these lesions are not well understood. CD105 (endoglin) is predominantly expressed in proliferating blood endothelial cells (ECs). We analyzed expressions of CD 105, CD34, von Willebrand factor, Ki-67, cyclooxygenase-2 (COX-2), and vascular endothelial growth factor (VEGF)-A in 31 capillary hemangiomas and 34 cavernous hemangiomas. Staining scores were calculated as the product of the proportion score and intensity score. Morphologically normal oral mucosa specimens (n = 10) were simultaneously evaluated as normal controls. As compared with cavernous hemangiomas and normal controls, capillary hemangiomas had higher staining scores for CD105, VEGF-A, and COX-2. The Ki-67 labeling index was significantly higher in capillary hemangiomas than in cavernous hemangiomas and normal controls (P< 0.01). These findings suggest that the biological characteristics of capillary and cavernous hemangiomas are quite different. The ECs of capillary |
| DOI | 10.2334/josnusd.57.45 |