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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Ontogeny of the murine Ig joining chain gene and protein |
| 掲載誌名 | 正式名：Scandinavian Journal of Immunology ISSNコード：03009475 |
| 出版社 | Wiley |
| 巻・号・頁 | 54(6),pp.613-618 |
| 著者・共著者 | M. Kimura,T. Takahashi,A. Iwata,N. Matsumoto,Y. Ogura,T. Akagi,S. Akima,K. Kobayashi,I. Moro |
| 発行年月 | 2001 |
| 概要 | We used Northern blot analysis in order to investigate the ontogeny of the murine joining (J)-chain gene. No J-chain expression was detected in embryonic tissues, including liver, spleen and intestine, but an expression of μ heavy chain was detected in foetal liver at day 17. J-chain expression was detected in the spleen at day 9 and in the intestine at day 15 after birth. Western blot analysis was carried out in order to compare the protein levels of J and μ heavy chains in serum from day 8 to day 24 after birth, using antihuman J chain and antimouse μ chain antibodies. Although μ chain protein could be detected in serum from day 8, J-chain protein was detectable only at day 24. These results suggest that the expression of J chain is a later event than the μ chain in the mouse, which thus differs in embryogenesis from humans. |
| DOI | 10.1046/j.1365-3083.2001.01016.x |
| PMID | 11902337 |