|
ナカヤマ リョウコ
Nakayama Ryoko
中山 亮子 所属 鶴見大学 歯学部 歯学科 病理学 職種 助教 |
|
| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Mutation of epidermal growth factor receptor is associated with MIG6 expression |
| 掲載誌名 | 正式名：FEBS Journal ISSNコード：1742464X |
| 出版社 | Blackwell Publishing Ltd |
| 巻・号・頁 | 276(18),pp.5239-5251 |
| 著者・共著者 | Nagashima, Takeshi,Ushikoshi-Nakayama, Ryoko,Suenaga, Atsushi,Ide, Kaori,Yumoto, Noriko,Naruo, Yoshimi,Takahashi, Kaoru,Saeki, Yuko,Taiji, Makoto,Tanaka, Hiroshi,Tsai, Shih-Feng,Hatakeyama, Mariko |
| 発行年月 | 2009/09 |
| 概要 | Controlled activation of epidermal growth factor receptor (EGFR) is systematically guaranteed at the molecular level; however, aberrant activation of EGFR is frequently found in cancer. Transcription induced by EGFR activation often involves the coordinated expression of genes that positively and negatively regulate the original signaling pathway; therefore, alterations in EGFR kinase activity may reflect changes in gene expression associated with the pathway. In the present study, we investigated transcriptional changes after EGF stimulation with or without the EGFR kinase inhibitor Iressa in H1299 human non-small-cell lung cancer cells [parental H1299, H1299 cells that overexpress wild-type EGFR (EGFR-WT) and mutant H1299 cells that overexpress EGFR where Leu858 is substituted with Arg (L858R)]. The results obtained clearly demonstrate differences in transcriptional activity in the absence or presence of EGFR kinase activity, with genes sharing the same molecular functions showing distinct expression dynamics. The results show the particular enrichment of EGFR/ErbB signaling-related genes in a differentially expressed gene set, and significant protein expression of MIG6/RALT(ERRF |
| DOI | 10.1111/j.1742-4658.2009.07220.x |
| PermalinkURL | http://doi.wiley.com/10.1111/j.1742-4658.2009.07220.x |