|
ナカヤマ リョウコ
Nakayama Ryoko
中山 亮子 所属 鶴見大学 歯学部 歯学科 病理学 職種 助教 |
|
| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Cytochrome p450 induction and gonadal status alteration in common carp (Cyprinus carpio) associated with the discharge of dioxin contaminated effluent to the Hikiji River, Kanagawa Prefecture, Japan |
| 掲載誌名 | 正式名：Chemosphere ISSNコード：00456535 |
| 出版社 | PERGAMON-ELSEVIER SCIENCE LTD |
| 巻・号・頁 | 51(6),pp.491-500 |
| 著者・共著者 | Sakamoto, K Q,Nakai, K,Aoto, T,Yokoyama, A,Ushikoshi, R,Hirose, H,Ishizuka, M,Kazusaka, A,Fujita, S |
| 発行年月 | 2003 |
| 概要 | Accumulations of polychlorinated dibenzo-p-dioxins, dibenzofurans and coplanar polychlorinated biphenyls were analyzed in common carp (Cyprinus carpio) collected in the Hikiji River, Kanagawa Prefecture, Japan in which dioxin contaminated effluent was released during the period starting from November 1992 to March 2000. Higher levels of 2,3,7,8-tetrachlorinated dibenzo-p-dioxin toxic equivalents were observed in carps collected downstream to the dioxin release site (contaminated site) than the reference site. Modulations of cytochrome P450 (CYP) enzyme in liver; serum estrogen concentration and gonadal somatic index (GSI) were also measured as biomarkers for the contaminants. Total CYP content in livers was markedly higher in male and female carps from the contaminated site relative to the reference site fish. The expression level of the cytochrome P450 1A and Ethoxyresorufin 0-deethylase activity were significantly higher in female carps from the contaminated site than from the reference site. A lower level of plasma estrogen was observed in carps from the contaminated site. The GSI in female carps from the contaminated site was smaller than that recorded at the reference site. Th |
| DOI | 10.1016/S0045-6535(03)00005-5 |
| PermalinkURL | http://www.ncbi.nlm.nih.gov/pubmed/12615101 |
| researchmap用URL | http://orcid.org/0000-0002-6688-0413 |