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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | The novel zinc finger-containing transcription factor Osterix is required for osteoblast differentiation and bone formation |
| 掲載誌名 | 正式名：CELL ISSNコード：00928674 |
| 出版社 | CELL PRESS |
| 巻・号・頁 | 108(1),pp.17-29 |
| 著者・共著者 | K Nakashima,Zhou, X,G Kunkel,ZP Zhang,JM Deng,RR Behringer,B de Crombrugghe |
| 発行年月 | 2002/01 |
| 概要 | We have identified a novel zinc finger-containing transcription factor, called Osterix (Osx), that is specifically expressed in all developing bones. In Osx null mice, no bone formation occurs. In endochondral skeletal elements of Osx null mice, mesenchymal cells, together with osteoclasts and blood vessels, invade the mineralized cartilage matrix. However, the mesenchymal cells do not deposit bone matrix. Similarly, cells in the periosteum and in the condensed mesenchyme of membranous skeletal elements cannot differentiate into osteoblasts. These cells do, however, express Runx2/Cbfa1, another transcription factor required for bone formation. In contrast, Osx is not expressed in Runx2/Cbfa1 null mice. Thus, Osx acts downstream of Runx2/Cbfa1. Because Osx null preosteoblasts express typical chondrocyte marker genes, we propose that Runx2/Cbfa1-expressing preosteoblasts are still bipotential cells. |
| DOI | 10.1016/s0092-8674(01)00622-5 |
| PMID | 11792318 |