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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Osterix, a transcription factor for osteoblast differentiation, mediates antitumor activity in murine osteosarcoma |
| 掲載誌名 | 正式名：CANCER RESEARCH ISSNコード：00085472 |
| 出版社 | AMER ASSOC CANCER RESEARCH |
| 巻・号・頁 | 65(4),pp.1124-1128 |
| 著者・共著者 | Y Cao,ZC Zhou,B de Crombrugghe,K Nakashima,H Guan,XP Duan,SF Jia,ES Kleinerman |
| 概要 | Osterix is a novel zinc finger-containing transcription factor that is essential for osteoblast differentiation and bone formation. We hypothesized that osterix might have a role in osteosarcoma tumor growth and metastasis. Northern blot analysis showed that the mRNA level of osterix was decreased in two mouse ostcosarcoma cell lines comparedwith its level in normal mouse osteoblasts. Osterix expression was also decreased in three human osteosarcoma cell lines. Transfection of the osx gene into the mouse osteosarcoma cells inhibited tumor cell growth in vitro and in vivo and significantly reduced tumor incidence, tumor volume, and lung metastasis following intratibial injection. Osterix expression was also associated with decreased osteolysis. Using an in vitro migration assay, osterix suppressed the migration of tumor cells to lung extracts. These results suggest that osterix expression may play a role in osteosarcoma tumor growth and metastasis. |
| DOI | 10.1158/0008-5472.CAN-04-2128 |
| PMID | 15734992 |