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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Lack of Schnurri-2 expression associates with reduced bone remodeling and osteopenia |
| 掲載誌名 | 正式名：JOURNAL OF BIOLOGICAL CHEMISTRY ISSNコード：00219258 |
| 出版社 | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC |
| 巻・号・頁 | 282(17),pp.12907-12915 |
| 著者・共著者 | Yoshitomo Saita,Tsuyoshi Takagi,Keiichiro Kitahara,Michihiko Usui,Kohei Miyazono,Yoichi Ezura,Kazuhisa Nakashima,Hisashi Kurosawa,Shunsuke Ishii,Masaki Noda |
| 発行年月 | 2007/04 |
| 概要 | Regulation of bone remodeling determines the levels of bone mass and its imbalance causes major skeletal diseases such as osteoporosis. A zinc finger protein, Schnurri-2 (SHN-2), was recently demonstrated to regulate bone morphogenetic protein-dependent adipogenesis and lymphogenesis. However, the role of SHN-2 in bone is not known. Here, we investigated the effects of Shn-2 deficiency on bone metabolism and cell function in Shn-2-null mice. Lack of SHN-2 expression reduced bone remodeling by suppressing both osteoblastic bone formation and osteoclastic bone resorption activities in vivo. Shn-2 deficiency suppressed osterix and osteocalcin expression as well as in vitro mineralization. Conversely, Shn-2 overexpression enhanced osteocalcin promoter activity and bone morphogenetic protein-dependent osteoblastic differentiation. Shn-2 deficiency suppressed Nfatc1 and c-fos expression leading to reduction of tartrate-resistant acid phosphatase-positive cell development in vivo as well as in the cultures of bone marrow cells. These studies demonstrate that SHN-2 regulates the activities of critical transcription factors required for normal bone remodeling. |
| DOI | 10.1074/jbc.M611203200 |
| PMID | 17311925 |