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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Cnot7-null mice exhibit high bone mass phenotype and modulation of BMP actions |
| 掲載誌名 | 正式名：JOURNAL OF BONE AND MINERAL RESEARCH ISSNコード：08840431 |
| 出版社 | AMER SOC BONE&MINERAL RES |
| 巻・号・頁 | 22(8),pp.1217-1223 |
| 著者・共著者 | Kaoru Washio-Oikawa,Takahisa Nakamura,Michihiko Usui,Mitsuhiro Yoneda,Youichi Ezura,Isao Ishikawa,Kazuhisa Nakashima,Tetsuo Noda,Tadashi Yamamoto,Masaki Noda |
| 発行年月 | 2007/08 |
| 概要 | Cnot7 is a recently identified regulator of spermatogenesis in adult mice. Because Cnot7 binds to Tob, a BMP inhibitor shown to be involved in bone metabolism, we examined whether Cnot7 is involved in bone mass regulation by using adult Cnot7 deficient mice. Cnot7(-/-) mice exhibited a high bone mass phenotype. This was associated with an increase in bone formation rate but not with any alteration in bone resorption parameters. On BMP treatment, Cnot7(-/-) cells expressed higher levels of alkaline phosphatase compared with control cells. Direct BMP2 injection induced larger bone mass in Cnot7(-/-) calvaria than control in vivo. These observations revealed that Cnot7 is an endogenous suppressor of bone mass and inhibits BMP actions in osteoblasts. |
| DOI | 10.1359/JBMR.070411 |