ナカシマ カズヒサ   Nakashima Kazuhisa
  中島 和久
   所属   鶴見大学  歯学部 歯学科 薬理学
   職種   准教授
論文種別 【査読あり】 研究論文(学術雑誌)
言語種別 英語
査読の有無 査読あり
表題 Unloading-induced bone loss was suppressed in gold-thioglucose treated mice
掲載誌名 正式名:JOURNAL OF CELLULAR BIOCHEMISTRY
ISSNコード:07302312
出版社 WILEY-LISS
巻・号・頁 99(3),pp.845-852
著者・共著者 K. Hino,A. Nifuji,M. Morinobu,K. Tsuji,Y. Ezura,K. Nakashima,H. Yamamoto,M. Noda
発行年月 2006/10
概要 Loss of mechanical stress causes bone loss. However, the mechanisms underlying the unloading-induced bone loss are largely unknown. Here, we examined the effects of gold-thioglucose (GTG) treatment, which destroys ventromedial hypothalamus (VMH), on unloading-induced boneloss. Unloading reduced bone volume in control (saline-treated) mice. Treatment with GTG-reduced bone mass and in these GTG-treated mice, unloading-induced reduction in bone mass levels was not observed. Unloading reduced the levels of bone formation rate (BFR) and mineral apposition rate (MAR). GTG treatment also reduced these parameters and under this condition, unloading did not further reduce the levels of BFR and MAR. Unloading increased the levels of osteoclast number (Oc.N/BS) and osteoclast surface (Oc.S/BS). GTG treatment did not alter the basal levels of these bone resorption parameters. In contrast to control, GTG treatment suppressed unloading-induced increase in the levels of Oc.N/BS and Oc.S/BS. Unloading reduced the levels of mRNA expression of the genes encoding osteocalcin, type I collagen and Cbfa1 in bone. In contrast, GTG treatment suppressed such unloading-induced reduction of mRNA expression.
DOI 10.1002/jcb.20935