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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration |
| 掲載誌名 | 正式名：Journal of Cellular Biochemistry ISSNコード：07302312 |
| 巻・号・頁 | 101(4),pp.979-986 |
| 著者・共著者 | Chikako Hayashi,Susan Rittling,Tadayoshi Hayata,Teruo Amagasa,David Denhardt,Yoichi Ezura,Kazuhisa Nakashima,Masaki Noda |
| 発行年月 | 2007/07 |
| 概要 | Tumor malignancy is associated with several features such as proliferation ability and frequency of metastasis. Since tumor metastasis shortens patients' lifetime, establishment of therapy for anti-metastasis is very important. Osteopontin (OPN), which abundantly expressed in bone matrix, is involved in cell adhesion, migration, extracellular matrix (ECM) invasion and cell proliferation via interaction with its receptor, that is, αvβ3 integrin. OPN is believed to be a positive regulator of tumor metastasis in vivo. However, how OPN regulates metastasis is largely unknown. Here, we explore the role of OPN in cell migration. Serum from wild-type mice induced cell migration of B16 melanoma cells, while serum from OPN-deficient mouse suppressed this event. The presence of recombinant OPN significantly enhanced cell migration compared to albumin containing medium. OPN-induced cell migration was suppressed by inhibiting the ERK/MAPK pathway indicating that OPN-induced cell migration depends on this pathway. Overexpression of OPN in these cancer cells per se promoted cell proliferation and tended to increase B16 cell migration suggesting that OPN promotes bone metastasis by playing dual |
| DOI | 10.1002/jcb.21298 |
| PMID | 17390343 |