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ナカシマ カズヒサ
Nakashima Kazuhisa
中島 和久 所属 鶴見大学 歯学部 歯学科 薬理学 職種 准教授 |
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| 論文種別 | 【査読なし】 書評,文献紹介等 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Transcriptional mechanisms in osteoblast differentiation and bone formation |
| 掲載誌名 | 正式名：TRENDS IN GENETICS ISSNコード：01689525 |
| 出版社 | ELSEVIER SCIENCE LONDON |
| 巻・号・頁 | 19(8),pp.458-466 |
| 著者・共著者 | K Nakashima,B de Crombrugghe |
| 発行年月 | 2003/08 |
| 概要 | Osteoblasts, the cells responsible for bone formation, differentiate from mesenchymal cells. Here, we discuss transcription factors that are involved in regulating the multistep molecular pathwayof osteoblast differentiation. Runx2 and Osx, a newly identified zinc-finger-containing protein, are transcription factors that are expressed selectively and at high levels in osteoblasts. Null mutations of either leads to a complete absence of bone in mice. Runx2 plus its companion subunit Cbfbeta are needed for an early step in this pathway, whereas Osx is required for a subsequent step, namely the differentiation of preosteoblasts into fully functioning osteoblasts. The finding that Osx-null cells acquire a chondrocyte phenotype implies that Osx is a negative regulator of Sox9 and of the chondrocyte phenotype. This leads to the hypothesis that Osx might have a role in the segregation of osteoblasts from osteochondro-progenitors. We also discuss recent progress in studies of other transcription factors that affect skeletal patterning and development. |