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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | BMP-2 Enhances Lgr4 Gene Expression in Osteoblastic Cells |
| 掲載誌名 | 正式名：JOURNAL OF CELLULAR PHYSIOLOGY ISSNコード：00219541 |
| 出版社 | WILEY-BLACKWELL |
| 巻・号・頁 | 231(4),pp.887-895 |
| 著者・共著者 | Chantida Pawaputanon Na Mahasarakham,Yoichi Ezura,Makiri Kawasaki,Arayal Smriti,Shuichi Moriya,Takayuki Yamada,Yayoi Izu,Akira Nifuji,Katsuhiko Nishimori,Yuichi Izumi,Masaki Noda |
| 発行年月 | 2016/04 |
| 概要 | Osteoporosis is one of the most prevalent diseases and the number of patients suffering from this disease is soaring due to the increase in the aged population in the world. The severity of bone loss in osteoporosis is based on the levels of impairment in the balance between bone formation and bone resorption, two arms of the bone metabolism, and bone remodeling. However, determination of bone formation levels is under many layers of control that are as yet fully defined. Bone morphogenetic protein (BMP) plays a key role in regulation of bone formation while its downstream targets are still incompletely understood. Lgr4 gene encodes an orphan receptor and has been identified as a genetic determinant for bone mass in osteoporotic patients. Here, we examine the effects of BMP on the expression of Lgr4 in osteoblastic cells. Lgr4 gene is expressed in an osteoblastic cell line, MC3T3E1 in a time dependent manner during the culture. BMP treatment enhances Lgr4 mRNA expression at least in part via transcriptional event. When Lgr4 mRNA is knocked down, the levels of BMP-induced increase in alkaline phosphatase (Alp) activity and Alp mRNA are suppressed. BMP enhancement of Lgr4 gene expres |
| DOI | 10.1002/jcp.25180 |
| PMID | 26332449 |