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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. |
| 掲載誌名 | 正式名：J. Bone Miner. Res. ISSNコード：08840431 |
| 巻・号・頁 | 18(9),pp.1706-1715 |
| 著者・共著者 | Mikihiko Morinobu,Muneaki Ishijima,Susan R Rittling,Kunikazu Tsuji,Haruyasu Yamamoto,Akira Nifuji,David T Denhardt,Masaki Noda |
| 発行年月 | 2003/09 |
| 概要 | To clarify the role of OPN in bone formation under mechanical stress, we examined the expression and the function of OPN in bone using an expansion force-induced osteogenesis model. Our results indicated that OPN expression was enhanced during the bone formation and that OPN would be one of the positive factors for the bone formation under mechanical stress.<br />Bone formation is known to be stimulated by mechanical stress; however, molecules involved in stress-dependent regulation of bone formation have not yet been fully characterized. Extracellular matrix proteins such as osteopontin (OPN) could play a role in mediation of the mechanical stress signal to osteoblasts. However, the function of OPN in bone formation under mechanical force is not known. Therefore, we examined the expression and the role of OPN in bone formation in vivo under tensile mechanical stress.<br />Sagittal sutures of mice were subjected to expansion mechanical stress by setting orthodontic spring wires, and OPN expression during bone formation within the suture gap was examined.<br />Expansion of the sutures resulted in bone formation at the edges of the parietal bones within the sagittal suture. Immuno |
| DOI | 10.1359/jbmr.2003.18.9.1706 |
| PMID | 12968681 |