|
ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
|
| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. |
| 掲載誌名 | 正式名：J. Bone Miner. Res. ISSNコード：08840431 |
| 巻・号・頁 | 17(4),pp.661-667 |
| 著者・共著者 | Muneaki Ishijima,Kunikazu Tsuji,Susan R Rittling,Teruhito Yamashita,Hisashi Kurosawa,David T Denhardt,Akira Nifuji,Masaki Noda |
| 発行年月 | 2002/04 |
| 概要 | Recent development in three-dimensional (3D) imaging of cancellous bone has made possible true 3D quantification of trabecular architecture. This provides a significant improvement in the measures available to study and understand the mechanical functions of cancellous bone. We recently reported that the presence of osteopontin (OPN) was required for the effects of mechanical stress on bone as OPN-null (OPN-/-) mice showed neither enhancement of bone resorption nor suppression of bone formation when they were subjected to unloading by tail suspension. However, in this previous study, morphological analyses were limited to two-dimensional (2D) evaluation. Although bone structure is 3D and thus stress effect should be evaluated based on 3D parameters, no such 3D morphological features underlying the phenomenon have been known. To elucidate the role of OPN in mediating mechanical stress effect based on true quantitative examination of bone, we evaluated 3D trabecular structures of hindlimb bones of OPN-/- mice after tail suspension. Tail suspension significantly reduced 3D parameters of bone volume (BV/TV), trabecular number (Tb.N), trabecular thickness (Tb.Th), and anisotropy and inc |
| DOI | 10.1359/jbmr.2002.17.4.661 |
| PMID | 11918223 |