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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読なし】 研究論文（大学，研究機関紀要） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Enhancing effect of Tob deficiency on bone formation is specific to bone morphogenetic protein-induced osteogenesis. |
| 掲載誌名 | 正式名：J. Bone Miner. Res. ISSNコード：08840431 |
| 巻・号・頁 | 17(6),pp.1026-1033 |
| 著者・共著者 | Michihiko Usui,Yutaka Yoshida,Teruhito Yamashita,Kunikazu Tsuji,Ishikawa Isao,Tadashi Yamamoto,Akira Nifuji,Masaki Noda |
| 発行年月 | 2002/06 |
| 概要 | Tob is a recently reported novel bone morphogenetic protein (BMP) inhibitor, which originally was identified by West-Western procedure using ErbB2 as a probe and contains a nuclear localization signal. To further characterize the effects of Tob deficiency on BMP-induced new bone (NB) formation, we examined microcomputed tomography (microCT) on the cross-section of the bone induced by daily injection with BMP onto the calvariae of newborn mice. The calvariae of the saline-injected Tob-deficient (TD) mice were similar to those of the saline-injected or untreated wild-type (WT) mice. BMP injection locally produced NB on the calvaria in WT mice as known previously. In contrast to WT mice, BMP injection onto the calvariae of TD mice produced a calcified area in the cross-section of NB, which was more than that produced by BMP in the WT calvariae. In addition, the horizontal width and the vertical height of the NB induced by BMP in TD mice were several-fold more than those in WT mice. The effect of Tob deficiency on bone-forming activity was selective to the response to the injection with BMP because the levels of injury-induced NB formation examined by microCT 10 days after bone marrow |
| DOI | 10.1359/jbmr.2002.17.6.1026 |
| PMID | 12054157 |