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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Coordinated expression of H3K9 histone methyltransferases during tooth development in mice |
| 掲載誌名 | 正式名：HISTOCHEMISTRY AND CELL BIOLOGY ISSNコード：09486143 |
| 出版社 | SPRINGER |
| 巻・号・頁 | 143(3),pp.259-266 |
| 著者・共著者 | Taichi Kamiunten,Hisashi Ideno,Akemi Shimada,Yoshiki Nakamura,Hiroshi Kimura,Kazuhisa Nakashima,Akira Nifuji |
| 発行年月 | 2015/03 |
| 概要 | Tissue-specific gene expression is subjected to epigenetic and genetic regulation. Posttranslational modifications of histone tails alter the accessibility of nuclear proteins to DNA, thus affecting the activity of the regulatory complex of nuclear proteins. Methylation at histone 3 lysine 9 (H3K9) is a crucial modification that affects gene expression and cell differentiation. H3K9 is known to have 0-3 methylation states, and these four methylated states are determined by the expression of sets of histone methyltransferases. During development, teeth are formed through mutual interactions between the mesenchyme and epithelium via a process that is subjected to the epigenetic regulation. In this study, we examined the expression of all H3K9 methyltransferases (H3K9MTases) during mouse tooth development. We found that four H3K9MTases-G9a, Glp, Prdm2, and Suv39h1-were highly expressed in the tooth germ, with expression peaks at around embryonic days 16.5 and 17.5 in mice. Immunohistochemical and in situ hybridization analyses revealed that all four H3K9MTases were enriched in the mesenchyme more than in the epithelium. Substrates of H3K9MTases, H3K9me1, H3K9me2, and H3K9me3 were also |
| DOI | 10.1007/s00418-014-1284-0 |
| PMID | 25294562 |