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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Promotion of Bone Formation around Alendronate-immobilized Screw-Type Titanium Implants after Implantation into Rat Molar Tooth Sockets |
| 掲載誌名 | 正式名：JOURNAL OF HARD TISSUE BIOLOGY ISSNコード：13417649 |
| 出版社 | JOURNAL HARD TISSUE BIOLOGY |
| 巻・号・頁 | 23(2),pp.177-186 |
| 著者・共著者 | Yuki Raita,Koichiro Komatsu,Akira Nifuji,Mitsunobu Sato,Mitsuhiko Morito,Tohru Hayakawa |
| 発行年月 | 2014/04 |
| 概要 | The aim of this study was to evaluate the effects of alendronate immobilization on bone formation following the implantation of apatite-coated titanium implants in rats. Thin carbonate-containing apatite coatings were deposited onto titanium implants (Ti implants) using a molecular precursor method. Alendronate was then immobilized on apatite-coated titanium implants (HA implants) by immersing the HA implants in alendronate solution (Aid implants). The rat molars were extracted, and the implants were immediately placed in the tooth sockets. Bone labeling was performed 14 and 7 days before sacrifice. At 3 and 9 weeks after implantation, undecalcified sections were prepared and bone histomorphometry was performed. Greater bone mass was found around the Aid implants than around either the Ti or HA implants at both 3 weeks and 9 weeks. At 3 weeks, fluorochrome bone labeling was greater around the Ald implants than around the Ti implants, and the values of bone to implant contact (BIC) and bone mass (BM) were significantly greater around the Ald implants than around the HA and Ti implants. At 9 weeks, bone labeling decreased and the values of BIC and BM increased compared with those at |
| DOI | 10.2485/jhtb.23.177 |