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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | G9a is involved in the regulation of cranial bone formation through activation of Runx2 function during development. |
| 掲載誌名 | 正式名：Bone |
| 巻・号・頁 | 137,pp.115332-115332 |
| 著者・共著者 | Hisashi Ideno,Kazuhisa Nakashima,Koichiro Komatsu,Ryoko Araki,Masumi Abe,Yoshinori Arai,Hiroshi Kimura,Yoichi Shinkai,Makoto Tachibana,Akira Nifuji |
| 担当区分 | 責任著者 |
| 発行年月 | 2020/04 |
| 概要 | The methyltransferase G9a was originally isolated as a histone methyltransferase that catalyzes the methylation of histone 3 lysine 9 (H3K9) to a dimethylated state (H3K9me2). Recent studies have revealed that G9a has multiple functions in various cells, including osteoblasts. Here, we investigated G9a function during cranial bone formation. Crossing Sox9-cre with G9aflox/flox (fl/fl) mice generated conditional knockout mice lacking G9a expression in Sox9-positive neural crest-derived bone cells. Sox9-Cre/G9afl/fl mice showed severe hypo-mineralization of cranial vault bones, including defects in nasal, frontal, and parietal bones with opened fontanelles. |
| DOI | 10.1016/j.bone.2020.115332 |
| PMID | 32344102 |