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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin |
| 掲載誌名 | 正式名：JOURNAL OF EXPERIMENTAL MEDICINE ISSNコード：00221007 |
| 出版社 | ROCKEFELLER UNIV PRESS |
| 巻・号・頁 | 193(3),pp.399-404 |
| 国際共著 | 国際共著 |
| 著者・共著者 | M Ishijima,Rittling, SR,T Yamashita,K Tsuji,H Kurosawa,A Nifuji,DT Denhardt,M Noda |
| 発行年月 | 2001 |
| 概要 | To investigate the possible requirement for OPN in the transduction of mechanical signaling in bone metabolism in vivo, we examined the effect of unloading on the bones of OPN-/- mice using a tail suspension model. In contrast to the tail suspension-induced bone loss in wild-type mice, OPN-/- mice did not lose bone. Elevation of urinary deoxypyridinoline levels due to unloading was observed in wild-type but not in OPN-/- mice. Analysis of the mechanisms of OPN deficient-dependent reduction in bone on the cellular basis resulted in two unexpected findings. First, osteoclasts, which were increased by unloading in wild-type mice, were not increased by tail suspension ill OPN-/- mice. Second. measures of os |