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ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Perturbation of BMP signaling in somitogenesis resulted in vertebral and rib malformations in the axial skeletal formation |
| 掲載誌名 | 正式名：Journal of Bone and Mineral Research ISSNコード：08840431 |
| 出版社 | John Wiley and Sons Inc. |
| 巻・号・頁 | 12(3),pp.332-342 |
| 著者・共著者 | Akira Nifuji,Odile Kellermann,Yoshinori Kuboki,John M. Wozney,Masaki Noda |
| 発行年月 | 1997 |
| 概要 | Axial skeletons such as vertebrae, ribs, and scapulae develop from the embryonic somitic mesoderm through interactions withneural tube/notochord and skin ectoderm. Bone morphogenetic proteins (BMPs) seem to play important roles in these tissue interactions however, the relationship between BMP signaling and the early development of axial skeletons is poorly understood. In this report, we investigated possible roles of BMP signaling in axial skeletal formation. First, we describe the expression patterns of BMP4 and type I receptors for BMP during somitogenesis in chick embryos based on whole mount in situ hybridization. Next, the effects of BMP on axial skeletal morphogenesis were investigated by implantation of BMP proteins into the dorsal mesoderm at the time of somitogenesis. Transcripts for both BMP4 ligand and its receptors are expressed in the dorsal ectoderm and mesoderm. Implantation of BMP4 and BMP2 into the dorsal regions of embryos result in subsequent anomalies of vertebrae, ribs, and scapulae. The effects of BMP implantation on the skeleton are shown to be dependent upon the somitic stage. Vertebral anomalies are restricted to the dorsolateral elements of the vertebra |
| DOI | 10.1359/jbmr.1997.12.3.332 |
| PMID | 9076575 |