|
ニフジ アキラ
Nifuji Akira
二藤 彰 所属 鶴見大学 歯学部 歯学科 薬理学 職種 教授 |
|
| 論文種別 | 【査読なし】 書評,文献紹介等 |
| 言語種別 | 英語 |
| 査読の有無 | 査読なし |
| 表題 | Extracellular modulators regulate bone morphogenic proteins in skeletal tissue |
| 掲載誌名 | 正式名：Journal of Oral Biosciences ISSNコード：13490079 |
| 出版社 | Japanese Association for Oral Biology |
| 巻・号・頁 | 52(4),pp.311-321 |
| 著者・共著者 | Akira Nifuji,Hisashi Ideno,Rieko Takanabe,Masaki Noda |
| 発行年月 | 2010 |
| 概要 | Bone morphogenic proteins (BMP) are multifunctional growth factors and members of the TGF-β superfamily. They were identified based on their ability to initiate ectopic bone formation in non-skeletal tissue. To date,over 20 BMP family members have been identified and characterized as locally acting signal molecules. They function in development, differentiation, and disease in various tissues and species. BMP bind to type I and type II serine/threonine kinase BMP receptors, which phosphorylate intracellular Smad proteins. This triggers their translocation to the nucleus, where they activate the transcription of target genes.There are many BMP modulators which function at multiple levels: extracellular, membranous, and intracellular.Extracellular BMP modulators contain a cysteine-rich (CR) domain characterized by a con-served structural motif known as a cystine knot. They are classified according to the number of amino acids contained in the cystine-knot ring ', the three classes include the eight-, nine-, and ten-membered ring cystine knots. The proteins bind to various BMP ligands, block ligand-receptor binding, and inhibit BMP signaling. They also function as BMP activators in c |
| DOI | 10.2330/joralbiosci.52.311 |