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イデノ ヒサシ
Ideno Hisashi
出野 尚 所属 鶴見大学 歯学部 歯学科 薬理学 職種 講師 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells |
| 掲載誌名 | 正式名：NATURE ISSNコード：00280836 |
| 出版社 | NATURE PUBLISHING GROUP |
| 巻・号・頁 | 494(7435),pp.100-104 |
| 著者・共著者 | Ryoko Araki,Masahiro Uda,Yuko Hoki,Misato Sunayama,Miki Nakamura,Shunsuke Ando,Mayumi Sugiura,Hisashi Ideno,Akemi Shimada,Akira Nifuji,Masumi Abe |
| 発行年月 | 2013/02 |
| 概要 | The advantages of using induced pluripotent stem cells (iPSCs) instead of embryonic stem (ES) cells in regenerative medicine centre around circumventing concerns about the ethics of using ES cells and the likelihood of immune rejection of ES-cell-derived tissues(1,2). However, partial reprogramming and genetic instabilities in iPSCs(3-6) could elicit immune responses in transplant recipients even when iPSC-derived differentiated cells are transplanted. iPSCs are first differentiated into specific types of cells in vitro for subsequent transplantation. Although model transplantation experiments have been conducted using various iPSC-derived differentiated tissues(7-10) and immune rejections have not been observed, careful investigation of the immunogenicity of iPSC-derived tissue is becoming increasingly critical, especially as this has not been the focus of most studies done so far. A recent study reported immunogenicity of iPSC- but not ES-cell-derived teratomas(11) and implicated several causative genes. Nevertheless, some controversy has arisen regarding these findings(12). Here we examine the immunogenicity of differentiated skin and bone marrow tissues derived from mouse iPSCs |
| DOI | 10.1038/nature11807 |
| PMID | 23302801 |