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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | In vivo morphometric analysis of inflammatory condylar changes in rat temporomandibular joint |
| 掲載誌名 | 正式名：ORAL DISEASES ISSNコード：1354523X |
| 出版社 | WILEY |
| 巻・号・頁 | 17(5),pp.499-507 |
| 著者・共著者 | Y. Kuroki,K. Honda,N. Kijima,T. Wada,Y. Arai,N. Matsumoto,K. Iwata,T. Shirakawa |
| 発行年月 | 2011/07 |
| 概要 | Objective:Injection of complete Freund's adjuvant (CFA) into the temporomandibular joint (TMJ) causes acute swelling around the joint and subsequent morphological alterations in the condyle. We aimed to evaluate changes in the three-dimensional architecture of the condyle induced with CFA.Materials and methods:The CFA was injected into the unilateral TMJ of rats and morphological changes in the condyle were assessed repeatedly for 14 days by in vivo micro-CT.Results:Osseous abnormalities of condyle were first observed at 3-5 days after CFA injection on the tomographic images, and the condylar deformation became more obvious thereafter. Among 12 condyles examined at 14 days postinjection, osteophytosis was observed in all of the specimens and bone erosion coexisted in five condyles. None of the saline-treated condyles showed architectural changes. Significant changes were detected in the mesiolateral and rostrocaudal widths of the CFA-treated condyles at 10-14 days postinjection (P< 0.01). The extent of both condylar bone formation and resorption was greater in the CFA-injected TMJs than in saline-injected TMJs (P< 0.05).Conclusion:These results indicate that CFA caus |
| DOI | 10.1111/j.1601-0825.2010.01782.x |