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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Secretory leukocyte protease inhibitor inhibits expression of polymeric immunoglobulin receptor via the NF-kappa B signaling pathway |
| 掲載誌名 | 正式名：MOLECULAR IMMUNOLOGY ISSNコード：01615890 |
| 出版社 | PERGAMON-ELSEVIER SCIENCE LTD |
| 巻・号・頁 | 67(2),pp.568-574 |
| 著者・共著者 | Yoshikazu Mikami,Takashi Iwase,Yusuke Komiyama,Naoyuki Matsumoto,Hidero Oki,Kazuo Komiyama |
| 発行年月 | 2015/10 |
| 概要 | Polymeric immunoglobulin receptor (pIgR) plays an important role in mucosal immune systems. Secretory immunoglobulin A, composed of secretory component of pIgR and a dimeric form of immunoglobulin A, is secreted on mucosal surfaces and serves as a biological defense factor. pIgR gene expression is reportedly induced by activation of the transcription factor nuclear factor (NF)-kappa B. On the other hand, secretory leukocyte protease inhibitor (SLPI) is a glycoprotein that functions as a serine protease inhibitor. In alveolar epithelial cells, SLPI increases the level of I kappa B beta, which indicates that it is an inhibitor of NF-kappa B at the protein level. Taken together, SLPI may regulate plgR expression; however, the specific mechanism by which this occurs is unclear. Therefore, the aim of this study was to elucidatethe influence of SLPI on pIgR expression. SLPI and pIgR localized in goblet cells and ciliated epithelial cells of the gastrointestinal tract, respectively. No cells were detected in which SLPI and pIgR were co-expressed. In addition, recombinant human SLPI stimulation of an epithelial cell line (HT-29) decreased the pIgR expression. The pIgR expression was also h |
| DOI | 10.1016/j.molimm.2015.07.021 |