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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Anaplastic large cell lymphoma in gingiva: case report and literature review |
| 掲載誌名 | 正式名：Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology ISSNコード：10792104 |
| 出版社 | Elsevier BV |
| 巻・号・頁 | 106(4),pp.e29-e34 |
| 著者・共著者 | Naoyuki Matsumoto,Hidero Ohki,Shotaro Mukae,Yusuke Amano,Daisuke Harada,Satoshi Nishimura,Kazuo Komiyama |
| 発行年月 | 2008/10 |
| 概要 | We report an unusual case of gingival anaplastic large-cell lymphoma (ALCL) that occurred in a 76-year-old Japanese woman who showed marked gingival swelling in both the maxilla and mandible. Although the patient received caries and periodontal therapy at the outpatient clinic of our dental hospital, the gingival swelling remained and she was referred to the oral surgery department, where a biopsy of the gingiva was performed. The specimens showed proliferation of large atypical and amphophilic epithelioid cells beneath the covering epithelium. Immunohistochemical analysis of the proliferating cells revealed positivity for CD30 and T-cell markers, such as CD45RB, as well as CD45RO antibodies, and they were weakly positive for the granzyme B antibody. In contrast, the tumor cells were negative for all B-cell markers as well as for CD3, CD56, S-100 protein, epithelial membrane antigen, and p80NPM/ALK antibodies. Based on the clinical and histopathologic features, the lesion was diagnosed as an ALCL in both the upper and the lower gingiva. This is an extremely rare case, in which a specific subtype of T-cell lymphoma appeared in the oral cavity. © 2008 Mosby, Inc. All rights reserved |
| DOI | 10.1016/j.tripleo.2008.05.037 |
| PMID | 18656392 |