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マツモト ナオユキ
Matsumoto Naoyuki
松本 直行 所属 鶴見大学 歯学部 歯学科 病理学 職種 教授 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Observation of the tarsus joint in the Mop-3/Bmal-1 gene knock-out mouse using"in vivo"micro-CT: Influence of diet and sex on calcification of the tendon of the tarsus joint |
| 掲載誌名 | 正式名：Journal of Hard Tissue Biology ISSNコード：13417649 |
| 巻・号・頁 | 21(2),pp.133-140 |
| 著者・共著者 | Yukiko Kai,Kunihito Matsumoto,Shigeo Kameoka,Shuuji Arai,Naoyuki Matsumoto,Kazuo Komiyama,Shigeki Shimba,Kazuya Honda |
| 発行年月 | 2012 |
| 概要 | Objective of this study is to investigate whether diet or sex influences calcification of the tendon in the Mop-3/Bmal-1 gene knock-out mouse (Bmal-1 knock-out mouse) by comparing"in vivo"micro-computed tomography imaging, soft-tissue X-ray imaging, and histologic evaluation as the 'gold standard'. 23 mice were placed into 8 groups according to genetic background, diet and sex. They underwent micro-CT imaging at magnifications of ×1.5, ×4.0, and ×10.0, and soft-tissue X-ray imaging. We compared 37 tendons in each of the 8 groups that showed calcification on micro-CT ×10.0 and on histologic evaluation. On micro-CT×1.5 images, 8 of the 21 joints of Bmal-1 knock-out mice showed calcification, and calcification was seen on micro-CT×4.0 images in 19 of 21 joints, and on micro-CT ×10.0 and SOFTEX, calcifications were seen in 20 of the 21 joints. For detecting calcifications, the diagnostic accuracy of micro-CT×1.5 was 0.68, that of micro-CT ×4.0 was 0.97, that of micro-CT ×10.0 and SOFTEX was 1.00. Regarding sex and diet, calcification was seen in 5 of 5 joints from males fed a high-fat diet, 4 of 4 joints from females fed a high-fat diet, 5 of 5 joints from males fed a regul |
| DOI | 10.2485/jhtb.21.133 |