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ハヤカワ トオル
Hayakawa Toru
早川 徹 所属 鶴見大学・鶴見大学短期大学部 学長・副学長 学長・副学長 副学長 職種 副学長 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Drug binding and releasing characteristics of DNA/lipid/PLGA film. |
| 掲載誌名 | 正式名：Dental materials journal 略 称：Dent Mater J ISSNコード：02874547/02874547 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 26(6),pp.854-60 |
| 著者・共著者 | Fukushima Tadao, Kawaguchi Minoru, Hayakawa Tohru, Takeda Shoji, Inoue Yusuke, Ohno Jun, Taniguchi Kunihisa |
| 発行年月 | 2007/11 |
| 概要 | We evaluated the blended compound of DNA/lipid complexes and PLGA (poly(D,L-lactide-co-glycolide)) as a carrier material for drug delivery system (DDS). Transparent, self-standing DNA/lipid/PLGA films were prepared by casting from an organic solvent such as DMSO/chloroform. Daunorubicin hydrochloride (DH) could intercalate and groove bind into DNA in the films, whereby the amount of DH bound to the films was controlled by the latter's immersion period in DH aqueous solution. DH was released from DH films after immersion in PBS solution, whereby release rate was dependent on the chemical structure of lipids. Released DH caused reduction of cell viability during the cell culture of L929 mouse fibroblasts. These results suggested that DNA/lipid/PLGA film was a promising useful material for DDS. |
| DOI | 10.4012/dmj.26.854 |
| PMID | 18203491 |