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ハヤカワ トオル
Hayakawa Toru
早川 徹 所属 鶴見大学・鶴見大学短期大学部 学長・副学長 学長・副学長 副学長 職種 副学長 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Gene expression of MC3T3-E1 cells on fibronectin-immobilized titanium using tresyl chloride activation technique. |
| 掲載誌名 | 正式名：Dental materials journal 略 称：Dent Mater J ISSNコード：02874547/02874547 |
| 掲載区分 | 国内 |
| 巻・号・頁 | 26(5),pp.647-55 |
| 著者・共著者 | Pugdee Kamolparn, Shibata Yasuko, Yamamichi Nobuyuki, Tsutsumi Haruhiko, Yoshinari Masao, Abiko Yoshimitsu, Hayakawa Tohru |
| 発行年月 | 2007/09 |
| 概要 | Fibronectin (FN) can be immobilized directly on titanium surfaces using tresyl chloride activation technique. The key advantage of tresyl chloride activation technique lies in its simplicity. In this study, we examined the cell attachment and gene expression of MC3T3-E1 cells on FN-immobilized titanium using GeneChip. Cells attached on FN-immobilized titanium at a higher rate than untreated titanium. FN altered the gene expression profile, whereby 62 genes were found to be up-regulated, while 56 genes were found to down-regulate to over twice the level on day 14. FN not only enhanced the expression levels of IBSP and OMD, but also decreased SULF1 mRNA level. Taken together, the immobilization of FN on tresylated titanium promoted early matrix mineralization and bone formation. |
| DOI | 10.4012/dmj.26.647 |
| PMID | 18203463 |