|
ナカヤマ リョウコ
Nakayama Ryoko
中山 亮子 所属 鶴見大学 歯学部 歯学科 病理学 職種 助教 |
|
| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Resveratrol improves salivary dysfunction in a non-obese diabetic (NOD) mouse model of Sjögren's syndrome |
| 掲載誌名 | 正式名：Journal of Clinical Biochemistry and Nutrition ISSNコード：09120009 |
| 出版社 | The Society for Free Radical Reseach Japan |
| 巻・号・頁 | 59(2),pp.107-112 |
| 著者・共著者 | Inoue, Hiroko,Kishimoto, Atsuhiro,Ushikoshi-Nakayama, Ryoko,Hasaka, Ayaka,Takahashi, Ayako,Ryo, Koufuchi,Muramatsu, Takashi,Ide, Fumio,Mishima, Kenji,Saito, Ichiro |
| 発行年月 | 2016/09 |
| 概要 | Resveratrol is a natural polyphenol produced by plants in response to environmental stress. This compound has been shown to have pharmacological effects against a wide range of diseases including neurological, hepatic, cardiovascular and autoimmune conditions. The non-obese diabetic (NOD) mouse, in which loss of lacrimal and salivary gland function occurs, has been studied as an animal model for Sjogren's syndrome. In this study, we confirmed that administration of resveratrol results in increased secretion of saliva in NOD mice. Although resveratrol enhanced Sirt1 activity, inflammatory cell infiltration was not affected. Moreover, expression of the anti-inflammatory cytokine IL-10 in salivary glands was enhanced in the resveratrol-administered group. Thus, we confirmed a novel therapeutic effect for resveratrol on salivary dysfunction in Sjogren's syndrome. |
| DOI | 10.3164/jcbn.16-31 |
| PermalinkURL | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018577/ |