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ナカヤマ リョウコ
Nakayama Ryoko
中山 亮子 所属 鶴見大学 歯学部 歯学科 病理学 職種 助教 |
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| 論文種別 | 【査読あり】 研究論文（学術雑誌） |
| 言語種別 | 英語 |
| 査読の有無 | 査読あり |
| 表題 | Evaluation of the effects of quercetin on damaged salivary secretion. |
| 掲載誌名 | 正式名：PloS one ISSNコード：19326203 |
| 出版社 | Public Library of Science |
| 巻・号・頁 | 10(1),pp.e0116008 |
| 著者・共著者 | Ayako Takahashi,Hiroko Inoue,Kenji Mishima,Fumio Ide,Ryoko Nakayama,Ayaka Hasaka,Koufuchi Ryo,Yumi Ito,Takashi Sakurai,Yoshinori Hasegawa,Ichiro Saito |
| 発行年月 | 2015 |
| 概要 | With the aim of discovering an effective method to treat dry mouth, we analyzed the effects of quercetin on salivary secretion and its mechanism of action. We created a mouse model with impaired salivary secretion by exposure to radiation and found that impaired secretion is suppressed by quercetin intake. Moreover, secretion levels were enhanced in quercetin-fed normal mice. To elucidate the mechanisms of these effects on salivary secretion, we conducted an analysis using mouse submandibular gland tissues, a human salivary gland epithelial cell line (HSY), and mouse aortic endothelial cells (MAECs). The results showed that quercetin augments aquaporin 5 (AQP5) expression and calcium uptake, and suppresses oxidative stress and inflammatory responses induced by radiation exposure, suggesting that quercetin intake may be an effective method to treat impaired salivary secretion. |
| DOI | 10.1371/journal.pone.0116008 |
| PMID | 25629520 |
| PermalinkURL | http://dx.plos.org/10.1371/journal.pone.0116008 |